Taking COBENFY™

(xanomeline and trospium chloride)

Kelsey is paid by BMS and not on COBENFY.

Start and end your day with COBENFY

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Take COBENFY twice daily by mouth

You can take 1 pill when you wake up and 1 pill before bed

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COBENFY on empty

Take COBENFY on an empty stomach

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Wait before you take

Wait at least 1 hour before eating or 2 hours after eating. Eating food too close to taking COBENFY can make side effects worse

Taking COBENFY 2 times per day may help keep the medicine at a consistent level in your body throughout the day.

A hand holding a pill

With COBENFY, taking control of your schizophrenia treatment is in the palm of your hand. Take COBENFY exactly as your healthcare provider tells you to take it. Do not miss a dose.

COBENFY comes in different strengths

COBENFY is made of xanomeline and trospium chloride. Your healthcare provider will determine which dose is right for you and may change your dose over time.

Infographic showing the starting dose and recommended dose of COBENFY

Pills not shown at actual size.
mg/mg is shown as xanomeline/trospium chloride.

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Do not change the dose, stop taking COBENFY without talking to your healthcare provider, or open the capsules. If you take too much COBENFY, call your healthcare provider or the Poison Help Line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

Tips to stay on track

It’s important to create a habit of taking COBENFY

 
  • Set phone alarms for the same times every day
  • Fit medications into your morning and night routine, like brushing your teeth
  • Use medicine organizers
  • Get questions answered with one-on-one support, 24/7. Call 1-877-COBENFY (1-877-262-3639)

Got your COBENFY Care Kit?

If you received sample wallets from your healthcare provider, you may have questions. Here are some of the most frequently asked:

Blue 3D box containing COBENFY Care Kit

COBENFY sample in a wallet packaging

Your sample wallet contains your first few doses of COBENFY, as prescribed by your healthcare provider. You’ll start with at least 2 days of the yellow 50-mg/20-mg dose, then increase to the brown 100-mg/20-mg dose for at least 5 days. After that, your healthcare provider will determine your ongoing dose.

When you are prescribed COBENFY, your healthcare provider may give you a sample wallet for your starting doses. Take COBENFY exactly as prescribed.

Sample wallets are available at no cost from your healthcare provider's office.

Three white pill bottles, each containing COBENFY at different dosages

Your first week is your body's introduction to the medicine. As you adjust, your dose may increase depending on how you respond. Your doctor will determine the right dose for you, and your dose may change over time. Depending on the dose, the COBENFY packaging may look different. Most likely, the 50-mg dose will include yellow on the packaging, 100-mg dose will include purple, and 125-mg dose will include pink.

Your sample wallet will be marked by dose strength and labeled by day. Take COBENFY exactly as your healthcare provider tells you. Do not change the dose or stop taking COBENFY without first talking to your healthcare provider. Take 1 COBENFY capsule 2 times each day. Take COBENFY by mouth at least 1 hour before a meal or at least 2 hours after a meal. Do not open the capsules. If you take too much COBENFY, call your healthcare provider or Poison Help Line at 1-800-222-1222, or go to the nearest hospital emergency room right away.

The sample wallets are laid out so you can see which pills have been removed, so you'll know how many you have left.

Get answers to your questions about taking COBENFY

Read common questions and answers about how to make COBENFY part of your routine.

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Cobenfy, Cobenfy Cares, and the Cobenfy logo are trademarks of Karuna Therapeutics, Inc., a Bristol Myers Squibb company.
© 2025 Bristol-Myers Squibb Company. 
1629-US-2500035 03/25
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