Frequently
asked questions

Actor portrayals.

Below is a list of frequently asked questions. Talk to your healthcare provider about these questions or any other questions you may have.

About COBENFY

COBENFY is a prescription medicine used to treat adults with schizophrenia. COBENFY is a unique combination of 2 medicines: xanomeline (Za-NO-muh-leen) and trospium (TRO-spee-um) chloride.

COBENFY is pronounced co-BEN-fee.

No, COBENFY is not an antipsychotic. COBENFY is the first and only FDA-approved schizophrenia medicine that is thought to work by activating small proteins in the brain called muscarinic acetylcholine receptors. The exact way COBENFY works is not fully understood.
Watch to see what makes COBENFY unique

No, COBENFY should not be refrigerated. It should be kept at room temperature (68 ˚F-77 ˚F).

COBENFY should be taken as long as your healthcare provider feels it is necessary. Do not stop taking COBENFY without first talking to your healthcare provider.

How to take COBENFY

Individual results vary, but most people in the clinical trials saw a significant improvement in 5 weeks. Ask your healthcare provider when to expect results and to clarify the goals of your treatment, including what you should look for to know if it’s working.

 

Learn more about results with COBENFY

Before taking COBENFY, tell your healthcare provider about all of your medical conditions, including if you:

  • have an enlarged prostate, problems passing urine, or a blockage in your urinary bladder
  • have liver problems
  • have or have had gallstones or problems with your bile ducts or pancreas
  • have stomach or intestinal problems, including constipation, ulcerative colitis, slow emptying of your stomach, or myasthenia gravis
  • have an eye condition called narrow-angle glaucoma
  • have kidney problems
  • are pregnant or plan to become pregnant. It is not known if COBENFY may harm your unborn baby. Tell your healthcare provider if you become pregnant or think you are pregnant during treatment with COBENFY
    • There is a pregnancy exposure registry for women who take COBENFY during pregnancy. The purpose of this registry is to collect information about the health of women exposed to COBENFY and their baby. If you become pregnant during treatment with COBENFY, your healthcare provider will register you by calling 1-866-961-2388 or online at https://womensmentalhealth.org/research/pregnancyregistry/atypicalantipsychotic/
  • are breastfeeding or plan to breastfeed. It is not known if COBENFY passes into your breast milk or if it can harm your baby

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking COBENFY with certain other medicines may increase your risk of side effects from COBENFY or the other medicine and may affect the way COBENFY or the other medicine works. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Reach out to your healthcare provider and ask them to repeat any information you didn’t understand at your appointment or to explain it differently—they may not realize they might be using confusing, scientific terms.

 

Also, think about including family or a trusted friend to join you at your next in-person or virtual appointment. They can help you better understand and remember your healthcare provider’s recommendations. 

Take COBENFY by mouth on an empty stomach—at least 1 hour before a meal or at least 2 hours after a meal. Eating food too close to taking COBENFY can make side effects worse.
 

Learn more about taking COBENFY

COBENFY is taken 2 times a day. This may help keep COBENFY at a consistent level in your body throughout the day. We recommend creating a routine where you take COBENFY at the start and end of the day. COBENFY Cares offers support that can help remind you to take COBENFY at the same time each day.
 

Learn more about dosing

If you miss a dose of COBENFY, you should talk to your healthcare provider.

There is no difference; both pills contain the exact same medicines.

Safety information and side effects

The most serious side effects of COBENFY include problems with emptying your bladder (urinary retention), risks in people with liver problems, risks in people with bile duct and gallbladder problems (biliary disease), slow emptying of your stomach (decreased gastrointestinal motility), serious allergic reactions (angioedema), an eye problem called narrow-angle glaucoma, increases in heart rate, side effects in people with kidney problems, and central nervous system problems.

The most common side effects of COBENFY include nausea, stomach upset or burning (dyspepsia), constipation, vomiting, high blood pressure, stomach (abdominal) pain, diarrhea, increased heart rate, dizziness, and heartburn (gastrointestinal reflux disease).

The average weight change in 5-week clinical studies was +3.04 lbs for people taking COBENFY vs +4.96 lbs for people taking a sugar pill. The average weight change in 1-year studies* was -5.64 lbs for people taking COBENFY.

 

*The results are from 1-year studies where participants and their physicians knew they were taking COBENFY, which may have influenced the results.
17.6% of people lost weight, while 4.1% gained weight.

In two 5-week clinical studies, 2% of people who took COBENFY experienced uncontrolled facial or body movements vs less than 1% of people taking a sugar pill.

If you experience nausea and/or vomiting, talk to your healthcare provider before you stop taking COBENFY.
 

Learn more about potential side effects

Tell your healthcare provider immediately if you experience a side effect. You may also report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Savings and cost

COBENFY Cares™ is a patient support program for those who have been prescribed COBENFY. COBENFY Cares Champions are available to answer questions, help identify financial resources and support, and assist you in following your medication schedule as your healthcare provider has prescribed.

 

For questions about the program, please call 1-877-COBENFY (1-877-262-3639).

The Wholesale Acquisition Cost (WAC), also known as list price, is $1,850 for 30 days of COBENFY. However, the WAC may not reflect the price paid by customers. People with insurance may pay less than the WAC price.

 

Learn more about the cost of COBENFY

There may be different cost-saving options for COBENFY, depending on insurance coverage and financial needs. If you’ve been prescribed COBENFY, contact COBENFY Cares™ to better understand the options available to you.

 

Learn more about pricing

COBENFY Cares™ can help you determine your out-of-pocket costs for COBENFY as well as your eligibility for the co-pay savings offer. Certain terms and conditions apply.
 

Learn more about coverage options

Bring the COBENFY Co-Pay Card to the pharmacy counter at the time the prescription is filled. Eligible participants may pay as little as $0 per 30-day supply. Please see COBENFY Terms and Conditions. For questions about the program, including savings on mail-order prescriptions, please call 1-877-COBENFY (1-877-262-3639).

COBENFY is a prescription medication. You and your healthcare provider will decide together if it's right for you. It is available at most retail and mail-order pharmacies with a prescription from your healthcare provider.

Are you or a loved one taking COBENFY to treat schizophrenia? Do you have an interest in sharing your story? If you’re a U.S. resident and 18 years or older, please call 1-855-436-5866 to find out if you are eligible to participate in our Ambassador Program.

Please note that not all candidates will be selected to participate in the program.



Cobenfy, Cobenfy Cares, and the Cobenfy logo are trademarks of Karuna Therapeutics, Inc., a Bristol Myers Squibb company.
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This website is intended for U.S. residents 18 years of age or older.