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Feel the relief of improved schizophrenia symptoms
Schizophrenia can be disruptive to your daily life. Even though it's not a cure, COBENFY may help you feel relief of your schizophrenia symptoms.
In 2 clinical studies, COBENFY*:
Delivered significant symptom relief vs placebo (sugar pill)
Showed overall improvement in a range of symptoms, including positive symptoms, like hallucinations and delusions, and negative symptoms, like lack of interest or emotion
In 1 clinical study, COBENFY†:
Reduced the overall severity of schizophrenia
COBENFY was studied in two 5-week clinical studies with 470 adults aged 18 to 65 diagnosed with schizophrenia. Participants either took COBENFY or a sugar pill.
Individual results may vary.
| * | A schizophrenia rating scale was used to compare meaningful changes in symptoms overall. These symptoms included positive, negative, and general psychopathology symptoms. |
| † | Another schizophrenia rating tool was used to evaluate meaningful overall changes in the severity of schizophrenia. |
The most common side effects of COBENFY include:
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These are not all of the possible side effects of COBENFY. Your healthcare provider may lower your dose or stop treatment with COBENFY if you get certain side effects.
COBENFY may cause serious side effects, including:
Problems with emptying your bladder (urinary retention), risks in people with liver problems, risks in people with bile duct and gallbladder problems (biliary disease), slow emptying of your stomach (decreased gastrointestinal motility), serious allergic reactions (angioedema), an eye problem called narrow-angle glaucoma, increases in heart rate, side effects in people with kidney problems, and central nervous system problems.
Similar rates of uncontrolled facial or body movements while taking COBENFY (2%) vs taking a sugar pill (<1%).
Nausea and vomiting often occurred within the first 2 weeks of treatment and generally decreased over time
If you experience nausea or vomiting, ask your healthcare provider about options that may help.
COBENFY effects on weight
| ‡ | The results are from 1-year studies where people knew they were taking COBENFY. These ongoing studies are less rigorous, and the data is not yet finalized. |
| § | 17.6% of people lost weight, while 4.1% gained weight. |
COBENFY is not an antipsychotic. It works differently
COBENFY is a different approach to schizophrenia treatment. COBENFY is a unique combination of 2 medicines: xanomeline and trospium chloride.
Xanomeline (Za-NO-muh-leen) is thought to activate muscarinic receptors in your brain to help adjust important chemical messengers related to schizophrenia symptoms.
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Trospium (TRO-spee-um) chloride may help prevent xanomeline from working outside your brain so that other parts of your body are less likely to be impacted.
The exact way COBENFY works is not fully understood.
COBENFY is the first and only FDA-approved schizophrenia medicine that is thought to work by activating small proteins in the brain called muscarinic acetylcholine receptors.
The xanomeline component of COBENFY activates specific muscarinic receptors in the brain that may be related to schizophrenia symptoms
The types of muscarinic receptors activated by COBENFY are thought to be found in specific areas of the brain associated with schizophrenia symptoms. Symptoms can happen when these areas have too many or too few important chemical messengers.
When the xanomeline component of COBENFY activates receptors in the brain, it may help to adjust the levels of important chemical messengers involved in schizophrenia.
How does your brain work?
Your brain is made up of billions of cells that help you think, learn, move, sleep, and more.
These cells need to work together and communicate with each other. They do this by sending each other chemical messengers.
What’s happening in your brain when you have schizophrenia?
Schizophrenia is a serious mental health condition that’s connected to what’s happening in your brain.
When you have schizophrenia, the amounts of certain kinds of chemical messengers in your brain may be too high or too low. This may lead to symptoms like hallucinations, feeling unmotivated, and having trouble with memory and learning.
